Formulation: 500 μl of Protein A-purified polyclonal antibody
Immunogen: Purified iNOS from cytokine-induced mouse macrophages (RAW 264.7) cells
Shelf life (days): 1095
Notes: Nitric Oxide Synthase (NOS) catalyzes the biosynthesis of nitric oxide from L-arginine. Constitutively expressed NOS is found in brain (nNOS) and endothelial cells (eNOS). iNOS is a soluble enzyme found in a variety of tissues including macrophages, hepatocytes, vascular smooth muscle cells, and chondrocytes.{1243,4141} iNOS expression is increased by a variety of factors including LPS, IFN-γ, Il-1β, and TNF-α, whereas expression is deceased by dexamethasone.{1904,1970,2111,3440,4851} The enzyme has been cloned from several species including mouse, rat, and human with homology of at least 80% between these species.{4141} The calculated molecular weight of the protein from the deduced amino acid sequence is 130,000 - 131,000.{1243}
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