Abbreviation: ITPR2
Target Synonym: ANHD;CFAP48;INSP3R2;IP3R2;ITPR2
Conjugation: Unconjugated
UNIProt ID: Q14571
Background: The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human ITPR2
Dilution: IHC 1:50-1:200
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