Application Note: Anti-JARID1C Antibody has been tested by ELISA and Western Blots. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 175 kDa in the appropriate cell lysate or extract.
Concentration Value: neat
ELISA Dilution: 1:500
Western Blot Dilution: 1:1,000
General Disclaimer Note: This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
Immunogen: Anti-JARID1C Antibody was produced in rabbits by repeated immunizations with three different synthetic peptides containing sequences from the inner part of the mouse Jarid1c protein.
Physical State: Liquid (sterile filtered)
Purity and Specificity: Anti-Jarid1c Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. Cross reactivity with Jarid1c from other species not tested.
Background: Jarid1c is a histone demethylase which specifically demethylates lysine 4 of histone H3, thereby playing a internal role in the regulation of transcription and chromatin remodeling. Jarid1c demethylates the trimethylated and dimethylated lysine 4, but not the monomethylated form. Further, Jarid1c participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Mutations in the Jarid1c gene have been associated with X-linked mental retardation. Anti-Jarid1c Antibody is ideal for research in Epigenetics, Gene Expression and Neuroscience.
Low Endotoxin: No
English
Deutsch
