Abbreviation: JNK1/2/3
Conjugation: Unconjugated
UNIProt ID: P45983/P45984/P53779
Background: JNK belongs to MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation.JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1,JNK2,and JNK3
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human JNK1/2/3
Dilution: WB 1:500-1:2000,IHC 1:50-1:200,IF 1:50-1:200,IP 1:50-1:100
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