Abbreviation: KCNQ2
Target Synonym: KCNQ2;BFNC;EBN;EBN1;ENB1;HNSPC;KCNA11;KV7.2
Conjugation: Unconjugated
UNIProt ID: O43526
Background: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human KCNQ2
Dilution: WB 1:500-1:2000
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