(KD Validated) Smad4 Polyclonal Antibody, Rabbit

Abbreviation: Smad4

Target Synonym: SMAD4; DPC4; JIP; MADH4; MYHRS; SMAD family member 4

Conjugation: Unconjugated

UNIProt ID: Q13485

Background: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human Smad4

Dilution: WB 1:500-1:2000

• SKU: ELSE-AB-92374-200
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-E-AB-92374-200
• Green Labware: No
• Package Unit: 200 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine)
• Clonality: Polyclonal
• Application: Western Blotting
• Isotype: IgG
• Host: Rabbit