Application Note: Anti-KDM1B Antibody has been tested by ELISA. Specific conditions for reactivity should be optimized by the end user.
Concentration Value: neat
ELISA Dilution: 1:500
General Disclaimer Note: This product is for research use only and is not intended for therapeutic or diagnostic applications. Please contact a technical service representative for more information. All products of animal origin manufactured by Rockland Immunochemicals are derived from starting materials of North American origin. Collection was performed in United States Department of Agriculture (USDA) inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation. All properties listed are typical characteristics and are not specifications. All suggestions and data are offered in good faith but without guarantee as conditions and methods of use of our products are beyond our control. All claims must be made within 30 days following the date of delivery. The prospective user must determine the suitability of our materials before adopting them on a commercial scale. Suggested uses of our products are not recommendations to use our products in violation of any patent or as a license under any patent of Rockland Immunochemicals, Inc. If you require a commercial license to use this material and do not have one, then return this material, unopened to: Rockland Inc., P.O. BOX 5199, Limerick, Pennsylvania, USA.
Immunogen: Anti-KDM1B Antibody was produced in rabbits by repeated immunizations with two different synthetic peptides containing a sequence from the N-terminus and internal region of the human KDM1B protein.
Physical State: Liquid (sterile filtered)
Purity and Specificity: Anti-KDM1B Antibody is monospecific antiserum processed by delipidation and defibrination followed by sterile filtration. Cross reactivity with KDM1B from other species not tested.
Background: KDM1B is a histone demethylase that demethylates lysine 4 of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. KDM1B is able to demethylate both mono- and di-methylated lysine 4 of histone H3, but has no effect on tri-methylated lysine 4, mono-, di- or tri-methylated lysine 9, mono-, di- or tri-methylated lysine 27, mono-, di- or tri-methylated lysine 36 of histone H3, or on mono-, di- or tri-methylated lysine 20 of histone H4. KDM1B is also required for de novo DNA methylation of a subset of imprinted genes during oogenesis. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Anti-KDM1B is ideal for research in Epigenetics and Gene Expression.
Low Endotoxin: No
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