KNK 437, CAS 218924-25-5

HSP70 Inhibitor

Product Type: Inhibitor.

CAS No.: 218924-25-5.

MolecularFormula: C13H11NO4.

Molecular Weight: 245,2.

Source: Synthetic.

Purity: >98% (HPLC); NMR (Conforms).

Solubility: May be dissolved in DMSO (30 mg/ml).

Appearance: Off-white powder.

PubChem CID: 46195007.

Scientific Background: KNK 437 is an inhibitor of the acquisition of thermotolerance caused by the induction of HSPs, including HSP105, HSP70, and HSP40 in human colon carcinoma cells (1). It has also been tested in anti-tumor therapy of colorectal cancer (2).

References: 1. Yokota S., Kitahara M., and Nagata K. (2000) Cancer Res. 60 (11): 2942-2948. 2. Yang S., et al. (2020) Oncogene. 39: 249-261.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• SKU: STRSIH-599-5MG
• Manufacturer: Stressmarq Biosciences
• Manufacturer SKU: SIH-599-5MG
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK