(KO Validated) hnRNP E1/PCBP1 Polyclonal Antibody, Rabbit

Abbreviation: hnRNP E1/PCBP1

Target Synonym: PCBP1; HEL-S-85; HNRPE1; HNRPX; hnRNP-E1; hnRNP-X; poly(rC)-binding protein 1

Conjugation: Unconjugated

UNIProt ID: Q15365

Background: This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

Concentration: 1mg/mL

Immunogen: A synthetic peptide of human hnRNP E1/PCBP1

Dilution: WB 1:500-1:2000,IHC 1:50-1:200

• SKU: ELSE-AB-92424-60
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-E-AB-92424-60
• Green Labware: No
• Package Unit: 60 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus)
• Clonality: Polyclonal
• Application: Western Blotting, Immunohistochemistry
• Isotype: IgG
• Host: Rabbit