LAMTOR1 Polyclonal Antibody, Rabbit

LAMTOR1 Polyclonal Antibody, Rabbit
SKU
ELSE-AB-92391-60
Packaging Unit
60 µl
Manufacturer
Elabscience Biotechnology

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Abbreviation: LAMTOR1

Target Synonym: LAMTOR1; C11orf59; PDRO; Ragulator1; p18; p27RF-Rho; ragulator complex protein LAMTOR1

Conjugation: Unconjugated

UNIProt ID: Q6IAA8

Background: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human LAMTOR1

Dilution: WB 1:500-1:2000,IF 1:50-1:200
More Information
SKU ELSE-AB-92391-60
Manufacturer Elabscience Biotechnology
Manufacturer SKU ELA-E-AB-92391-60
Green Labware No
Package Unit 60 µl
Quantity Unit STK
Reactivity Human
Clonality Polyclonal
Application Immunofluorescence, Western Blotting
Isotype IgG
Host Rabbit
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