LIMK1 Polyclonal Antibody, Rabbit

Abbreviation: LIMK1

Target Synonym: LIMK1;LIMK;LIMK-1

Conjugation: Unconjugated

UNIProt ID: P53667

Background: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human LIMK1

Dilution: WB 1:500-1:2000

• SKU: ELSE-AB-93157-200
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-E-AB-93157-200
• Green Labware: No
• Package Unit: 200 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine), Rat (Rattus)
• Clonality: Polyclonal
• Application: Western Blotting
• Isotype: IgG
• Host: Rabbit