Lirafugratinib, CAS 2549174-42-5

Formulation: A solid

Formal Name: N-[4-[4-amino-5-[3-fluoro-4-[(4-methyl-2-pyrimidinyl)oxy]phenyl]-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-2-methyl-2-propenamide

Purity: ≥98%

Formula Markup: C28H24FN7O2

Formula Weight: 509,5

Shelf life (days): 1460

CAS Number: 2549174-42-5

Notes: Lirafugratinib is a covalent inhibitor of FGFR2 (IC50 = 0.003 µM).{68702} It is selective for FGFR2 over FGFR1, -3, and -4 (IC50s = 0.77, 0.26, and 15 µM, respectively). Lirafugratinib inhibits the proliferation of SNU-16 gastric cancer cells (IC50 = 0.002 µM). In vivo, lirafugratinib (10 mg/kg) reduces intratumoral FGFR2 phosphorylation and tumor volume in an FGFR2-amplified SNU-16 gastric cancer mouse xenograft model.

• SKU: CAY40940-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40940-10
• Package Unit: 10 mg
• Quantity Unit: STK