Application Note: WB: 0.1-0.5μg/mL. ICC/IF: 2μg/mL. IHC-P: 0.5-1μg/mL. FACS: 1-3μg/1x106 cells. ELISA: 0.1-0.5μg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 106
Form: Liquid
Buffer (with preservative): 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg sodium azide.
Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
Uniprot ID: P36776
Antigen Species: Human
Immunogen: E.coli-derived human LONP1/Lon recombinant protein (Position: R137-A320).
Purification: Purified by antigen-affinity chromatography
Conjugation: Unconjugated
Full Name: lon peptidase 1, mitochondrial
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