Products from BPS Bioscience require a minimum order value above 400€
Applications: Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Background: LSD1 is a chromatin-modifying enzyme that specifically removes methyl groups from mono- and dimethylated Lys of histone H3. LSD1 is a critical component of transcriptional regulation via epigenetic histone modifications and is therefore a potential target for drug development.
Description: The LSD1 Homogeneous Assay Kit is designed to measure activity oflysine-specific demethylase (LSD1) for screening and profiling applications. The key to the LSD1 HomogeneousAssay Kit is a highly specific antibody that recognizes demethylated substrate. With thiskit, only three simple steps on a microtiter plate are required for demethylase detection.First, a sample containing LSD1 enzyme is incubated with the biotinylated substrate. Next,acceptor beads and primary antibody are added, then donor beads, followed by readingthe Alpha-counts.
Storage Stability: 12 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival.
Uniprot: O60341
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Forneris F, et al. J Biol Chem 2006; 281(46):35289-95.
2. Zhou M, et al. Anal Biochem 1997; 253(2):162-8.
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