Product Description: m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Applications: Cancer-programmed cell death
Formula: C25H53NO12
References: [1]Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30(1):253-259./[2] Joseph Fox, et al. Methods for inducing bioorthogonal reactivity. WO2017106427A1.
CAS Number: 1977493-48-3
Molecular Weight: 559.69
Compound Purity: 99.74
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: ADC Linker;PROTAC Linkers