Application Note: WB: 1 - 2 μg/mL. IHC-P: 2.5 μg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 97
Positive Control: Mouse Liver Tissue Lysate(GTX27935) , Human Liver Tissue Slide , Human Liver Tissue Lysate
Form: Liquid
Buffer (with preservative): PBS, 0.02% Sodium azide.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. MACC1 protein consists of four domains: ZU5, SH3, and two C-terminal death domains (DD). Expression of MACC1 was found significantly upregulated in malignant tissues (colon cancer of all stages as well as liver and lung metastases) compared to normal tissues or adenomas. MACC1 represents an early and crucial prognostic indicator for colon cancer metastasis that is independent of age, sex, tumor infiltration, nodal status, and lymph vessel invasion. Besides its involvement in signal transduction with the MET receptor, MACC1 also links MET signaling and apoptosis. MACC1 may also be an important therapeutic target for colorectal cancer treatment. At least two isoforms of MACC1 are known to exist.
Uniprot ID: Q6ZN28
Antigen Species: Human
Immunogen: MACC1 antibody was raised against a 17 amino acid synthetic peptide near the center of human MACC1.The immunogen is located within amino acids 430 - 480 of MACC1.
Purification: Purified by antigen-affinity chromatography
Conjugation: Unconjugated
Full Name: MET transcriptional regulator MACC1
English
Deutsch
