Description: Macrophage-activating lipopeptide 2 (MALP-2) is a lipopeptide that acts as an agonist for Toll-like receptors TLR-2 and TLR-6. It enhances the phosphorylation of endothelial nitric oxide synthase (eNOS) and the release of nitric oxide (NO) by endothelial cells, thereby improving vasodilation. Additionally, MALP-2 increases the adhesion of leukocytes to the endothelium and enhances perfusion recovery and collateral growth in the hind limbs of hypercholesterolemic Apoe-deficient mice subjected to experimental femoral artery ligation (FAL).