Formulation: A crystalline solid
Formal Name: glycyl-L-isoleucylglycyl-L-lysyl-L-phenylalanyl-L-leucyl-L-histidyl-L-seryl-L-alanylglycyl-L-lysyl-L-phenylalanylglycyl-L-lysyl-L-alanyl-L-phenylalanyl-L-valylglycyl-L-α-glutamyl-L-isoleucyl-L-methionyl-L-lysyl-L-serine, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C112H177N29O28S • XCF3COOH
Formula Weight: 2409,9
Shelf life (days): 1460
Notes: Magainin 1 is a cationic peptide originally isolated from the skin of the African clawed frog (X. laevis) with roles in host defense and antimicrobial activity.{65751} It reduces germination percentage and mean tube elongation in kiwi fruit pollen (EC50s = 14 and 15.8 µM, respectively).{65752} Magainin 1 decreases viral replication in Vero cells infected with herpes simplex virus 1 (HSV-1) or HSV-2 (EC50s = 36.59 and 33.2 µM, respectively) without affecting cell viability (CC50 = >100 µM).{65753} It induces apoptosis in HL-60 cells when used at concentrations of 10 and 50 µM and hemolysis in isolated human erythrocytes at 50 µM.{65754} Magainin 1 (10 and 50 µM) induces DNA fragmentation in HL-60 cells in a reporter assay.
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