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Encompassing Amino Acids: 2-497
Applications: Suitable for protein binding studies, as an immunogen, or as a protein standard for Western blotting.
Background: Monoamine Oxidases (MAO) catalyze the oxidation of monoamines such as dopamine, serotonin and adrenalin. They are found bound to the outer membrane of mitochondria in most cell types in the body. Two subtypes of monoamine oxidase have been identified: MAO-A and MAO-B. Both are found in neurons and astroglia, with MAO-A also found in the liver, gastrointestinal tract and placenta and MAO-B in blood platelets. Abnormal regulation of MAOs in the body has been associated with depression, substance abuse, attention deficit disorder, and irregular sexual maturation. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
Description: Human monoamine oxidase A (MAOA), GenBank Accession No. NM_000240, a.a. 2-497, with N-terminal His-tag and N-terminal FLAG-tag, MW = 58.2 kDa, expressed in a baculovirus infected Sf9 cell expression system.
Format: Aqueous buffer solution
Formulation: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 80 ?g/ml FLAG peptide, and 20% glycerol.
Genbank: NM_000240
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal His-tag, N-terminal FLAG-tag
Uniprot: P21397
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Hodorova, I., et al., Med. Sci. Monit. 2012;18(12):BR482-BR486.
2. Brunner, H.G., et al., Science. 1993;262(5133):578-580.
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