MAPK8IP1 Polyclonal Antibody, Rabbit

Abbreviation: MAPK8IP1

Target Synonym: MAPK8IP1;IB1;JIP-1;JIP1;PRKM8IP

Conjugation: Unconjugated

UNIProt ID: Q9UQF2

Background: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human MAPK8IP1

Dilution: WB 1:200-1:2000

• SKU: ELSE-AB-92930-120
• Manufacturer: Elabscience Biotechnology
• Manufacturer SKU: ELA-E-AB-92930-120
• Green Labware: No
• Package Unit: 120 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine)
• Clonality: Polyclonal
• Application: Western Blotting
• Isotype: IgG
• Host: Rabbit