Product Description: MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan (HY-13631) with IC50 of 22 μM. MC-Gly-Gly-Phe-Gly-GABA-Exatecan targets various antibodies, exhibits cytotoxic and antitumor efficacy in vitro and in vivo[1][2].
Applications: Cancer-programmed cell death
Formula: C53H58FN9O12
References: [1]Hettmann T, et al., Anti-her3 antibody-drug conjugate. Patent WO2015155998/[2]Ogitani Y, et al., Wide application of a novel topoisomerase I inhibitor-based drug conjugation technology. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5069-5072.
CAS Number: 1599439-52-7
Molecular Weight: 1032.08
Compound Purity: 99.72
Research Area: Cancer
Solubility: DMSO : 100 mg/mL (ultrasonic)
Target: Drug-Linker Conjugates for ADC;Topoisomerase