Product Description: MC-SN38 is a agent-linker conjugate composed of a potent microtubule-disrupting agent SN38 and a non-cleavable MC linker to make antibody agent conjugate (ADC). SN-38, an active metabolite of the Topoisomerase I inhibitor Irinotecan, inhibits DNA synthesis and causes frequent DNA single-strand breaks[1][2].
Applications: Cancer-programmed cell death
Formula: C32H31N3O8
References: [1]Jensen NF, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a newpair of resistance-associated mutations. J Exp Clin Cancer Res. 2016 Mar 31;35:56./[2]Kawato Y, et al. Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991;51(16):4187-4191.
CAS Number: 1473403-87-0
Molecular Weight: 585.60
Compound Purity: 98.65
Research Area: Cancer
Solubility: DMSO : 140 mg/mL (ultrasonic)
Target: Drug-Linker Conjugates for ADC
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