Methoxyamine (hydrochloride), CAS 593-56-6

Product Description: Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents[1][2].

Applications: Cancer-programmed cell death

Formula: CH6ClNO

References: [1]Sameer Agnihotri, et al. ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents. Cancer Discov. 2014 Oct;4(10):1198-213./[2]Samideh Khoei, et al. Effects of resveratrol and methoxyamine on the radiosensitivity of iododeoxyuridine in U87MG glioblastoma cell line. Exp Biol Med (Maywood). 2016 Jun;241(11):1229-36.

CAS Number: 593-56-6

Molecular Weight: 83.52

Compound Purity: 98.0

Research Area: Cancer

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: Apoptosis;DNA/RNA Synthesis

• SKU: MEXHY-Y0958-10.1
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-Y0958-10.1
• Package Unit: 10mM/1mL
• Quantity Unit: STK