Clone Name: MT3.1
Application Note: IHC-P: 1:20-1:40. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 22
Positive Control: Colon carcinoma
Form: Liquid
Buffer (with preservative): Tris-HCI buffer, 0.2% BSA, 0.09% Sodium azide.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015]
Uniprot ID: P16455
Antigen Species: Human
Immunogen: Purified recombinant human MGMT protein
Purification: Purified IgG
Conjugation: Unconjugated
Full Name: O-6-methylguanine-DNA methyltransferase
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