MI-2-2, CAS 1454920-20-7

Formulation: A solid

Formal Name: 4-[4-(4,5-dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(2,2,2-trifluoroethyl)-thieno[2,3-d]pyrimidine

Purity: ≥98%

Formula Markup: C17H20F3N5S2

Formula Weight: 415,5

Shelf life (days): 1460

CAS Number: 1454920-20-7

Notes: MI-2-2 is an inhibitor of the protein-protein interaction between menin and mixed-lineage leukemia 1 (MLL1).{23797} It binds to menin (Kd = 22 nM) and inhibits the interaction between menin and MLL1 in a cell-free assay (IC50 = 46 nM). MI-2-2 reduces cell growth (GI50 = 3 µM) and induces cell cycle arrest at the G1 phase in MV4-11 cells.

• SKU: CAY41109-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41109-5
• Package Unit: 5 mg
• Quantity Unit: STK