Application Note: IHC-Wm: 1:50-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 113
Form: Liquid
Buffer (with preservative): PBS, 20% Glycerol, 0.01% Thimerosal.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intestine. Essential for early embryonic development.
Uniprot ID: Q804S5
Antigen Species: Zebrafish
Immunogen: Recombinant protein encompassing a sequence within the N-terminus region of zebrafish Mib. The exact sequence is proprietary.
Purification: Purified by antigen-affinity chromatography.
Conjugation: Unconjugated
Full Name: mindbomb E3 ubiquitin protein ligase 1
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