Clone Name: G168-728
Light Chain: Kappa
Application Note: IHC-P: 1:25-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 85
Positive Control: Colon carcinoma
Form: Liquid
Buffer (with preservative): Tris-HCl buffer, 0.2% BSA, 0.09% Sodium azide.
Concentration: Batch dependent (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
Uniprot ID: P40692
Antigen Species: Human
Immunogen: Full length recombinant human MLH-1
Purification: Purified IgG
Conjugation: Unconjugated
Full Name: mutL homolog 1
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