Product Description: MMAF-Ome, an antitubulin agent, is also an ADC cytotoxin. MMAF-Ome inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively.
Applications: Cancer-programmed cell death
Formula: C40H67N5O8
References: [1]Currier NV, et al. Targeted Drug Delivery with an Integrin-Binding Knottin-Fc-MMAF Conjugate Produced by Cell-Free Protein Synthesis. Mol Cancer Ther. 2016 Jun;15(6):1291-300
CAS Number: 863971-12-4
Molecular Weight: 745.99
Compound Purity: 99.62
Research Area: Cancer
Solubility: DMSO : ≥ 100 mg/mL
Target: ADC Cytotoxin