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Applications: This kit is useful for screening for inhibitors of monkey PD-1 binding to PD-L1.
Description: Cell signaling through the PD-1 receptor upon binding the PD-L1 ligand attenuates immune responses and this pathway is exploited by both tumors and viruses. The Monkey PD-1:PD-L1[Biotinylated] Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of this signaling pathway in the animal model cynomolgus monkey (Macaca fascicularis).
Storage Stability: Stable at least 6 months from date of receipt, when stored as directed. Kit components require different storage conditions. Be sure to store each component at the proper temperature upon arrival,
Supplied As: This kit comes in a convenient 96-well format, with biotin-labeled monkey PD-L1, purified monkey PD-1, streptavidin-labeled HRP, and assay buffer for 100 binding reactions. The key to this kit is the high sensitivity of detection of biotin-labeled PD-L1
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Onlamoon, N. et al. Immunol. 2008, 124.1: 277-2932. Wang. C. et al. Cancer Immunol. Res. 2014, 2.9: 846-856
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