Clone Number: TH22
Immunogen: Prokaryotic recombinant protein corresponding to 118 amino acids of the human Carbonic Anhydrase IX molecule.
Concentration: Greater than or equal to 21 mg/L
Storage buffer: Tissue culture supernatant with 15mM sodium azide
Additional info: Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. Originally named MN/G250, carbonic anhydrase IX (CAIX) is a cell surface transmembrane protein, which is predominantly found in the gastrointestinal tract and gallbladder. The glandular regions of normal colon are reported to be negative, but in the case of adenocarcinoma, the glands are positive. CAIX is also reported to be expressed in common epithelial tumors such as carcinomas of the esophagus, lung, colon, kidney, cervix and non-small cell lung carcinoma.In breast carcinomas, CAIX expression has been reported to be associated with malignant tissue. Expression of CAIX is reported to be absent in normal kidney, chromophobe carcinomas or oncocytomas; however, it is specifically expressed in clear cell renal carcinomas.
References: Swietach P et al. Cancer and Metastasis Reviews. 2007; 26:299–310/Potter C and Harris A. Cell Cycle. 2004; 3(2):164–167
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