Mouse anti-CD22/B-cells, clone MEM-01 (Monoclonal)

Clone Number: MEM-01

Immunogen: Raji Burkitt's lymphoma cell line

Concentration: 1 mg/ml

Storage buffer: Phosphate buffered saline (PBS) solution with 15 mM sodium azide

Additional info: CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

• SKU: SANMON1067
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON1067
• Green Labware: No
• Package Unit: 0,1 mg
• Quantity Unit: STK
• Reactivity: Human, Primate
• Clonality: Monoclonal
• Application: Immunoprecipitation, Western Blotting, Flow Cytometry
• Isotype: IgG1
• Host: Mouse