Clone Number: 202-36
Immunogen: T-cell clone
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: 202-36 Reacts with human CD26 (Dipeptidyl peptidase IV), a 110 kDa protein which occurs in the cell membrane of T-lymphocyte and is upregulated after activation. CD26 is also present on endothelial cells and also expressed on activated B-cells and natural killer cells and abundantly on epithelia. CD26 is implicated in a variety of biological functions including T-cell activation, cell adhesion with extracellular matrix such as fibronectin or collagens, and in HIV infection. Crosslinking of CD26 using this antibody dramatically enhances the anti-CD3-induced IL-2 production. In Western blotting, this mAb reacts with only glycosylated CD26, but not with deglycosylated froms. It does not prevent ADA binding to CD26. The mAb was clustered at the VIth WLDA.
References: Kishimoto T. et al., eds. Leukocyte Typing VI, Garland Publishing, (1997)
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