Clone Number: F4-29D9
Immunogen: human umbilical vein endothelial cells
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: F4-29D9 reacts with CD55 or DAF (Decay Accelerating Factor). All leucocytes as well as human erythrocytes, fibroblasts, platelets, endothelial cells and neuroectodermal cells are positive for DAF. F4-29D9 also recognizes an antigen on spermatozoid cells. It is a glycosylphosphatidylinositol anchored (GPI-anchored) member of the membrane bound complement regulatory proteins that inhibit autologous complement cascade activation. CD55 also serves as receptor for CD97 and for echovirus and coxsackie B virus. DAF is deficient in both granulocytes and monocytes in patients with paroxysmal nocturnal haemoglobinuria.
References: Kishimoto T. et al., eds. Leukocyte Typing VI, p509-514, Garland Publishing, Inc, (1997)/B.E. Loveland - in Leucocyte Typing VI - Part 6 CD55 Workshop Panel Report pp519-520, (1997)/Ruix-Delgado, GJ et al, Hematology 14: 33-7 (2009)
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