Clone Number: EBS-CD-033
Immunogen: crude membrane preparation of a small cell lung cancer
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: EBS-CD-033 reacts with an extracellular domain (close to the cell membrane) of CD56/NCAM. Only 2 isoforms of NCAM are recognized by EBS-CD-033 (180 kDa and 145 kDa). EBS-CD-033 was used successfully for immunoscintigraphy and immunotherapy of SCLC xenografts in nude mice. EBS-CD-033 recognizes NCAM in retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell lung carcinomas. NCAM is also expressed on some mesodermally derived tumors (a.o. rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.
References: Schol DJ. et al, Int. J. Cancer Suppl.2: 35-40 (1988)/Kibbelaar RE. et al, Eur J Cancer 27(4): 431-5 (1991)/Brezicka FT. et al, APMIS. 99(9): 797-802 (1991)
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