Mouse anti-CD56, Neural Cell Adhesion Molecule, NCAM, clone 123C3 (Monoclonal), sample

Clone Number: 123C3

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: 100 ug/ml

Storage buffer: PBS with 0.1% BSA and 0.02% sodium azide

Additional info: The antibody recognizes a transmembrane glycoprotein of 140 and 180 kD which has been identified as NCAM (Neural Cell Adhesion Module). At the international Workshop on SCLC antibodies 123C3 has been categorized as cluster 1 antibody. All cells in small cell carcinomas and carcinoids of the lung are strongly positive for 123C3. A minority of cases of other major types of lung carcinoma are sometimes positive as well: however this positivity is generally weak and focal. Adenoid cystic carcinomas of bronchial glands are strongly positive. Neuroblastoma's and Wilms tumors are usually also staining strongly positive. In non-small lung cell carcinomas, 123C3 staining has been associated with more advanced stage and a decreased survival after surgery. Furthermore, this antibody can be used to support diagnosis of lymphoma or to detect residual disease for cases of CD56 positive T/NK -cell lymphoma in which the neoplastic lymphoid cells are small and show minimal atypia, especially in small biopsies.

References: Moolenaar et al. Cancer Res 1990;50:1102/Kibbelaar et al. Eur J Cancer 1991;27:431/Stahel et al. Int J Cancer suppl 1994;8:6

• SKU: SANMON9006-1
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON9006-1
• Green Labware: No
• Package Unit: 1 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunofluorescence, Immunohistochemistry (frozen), Immunohistochemistry (paraffin)
• Isotype: IgG1
• Host: Mouse