Clone Number: MRQ-56
Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers
Concentration: n/a
Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Additional info: CD7 antigen is a 40-kDa cell surface glycoprotein that is a member of the immunoglobulin gene superfamily. While its precise function is not known, it is suggested that CD7 plays a role in T-cell interactions as it is one of the earliest T-cell lineage associated antigens expressed during T-cell ontogeny. CD7 is expressed in thymocytes, mature peripheral T-cells, natural killer cells, and lymphoid and myeloid progenitors. CD7 is the most consistently expressed T cell antigen in lymphoblastic lymphomas and leukemias, and is therefore a useful marker in the identification of such neoplastic proliferations. In mature post-thymic T cell neoplasms, it is the most common pan-T antigen to be aberrantly absent and its absence in a T cell population is a useful pointer to a neoplastic conversion.
References: Hodak E, et al. J Am Acad Derma¬tol. 2006 Aug;55(2):276-84/Stillwell R, et al. Immunol Res. 2001; 24:31-52/Schanberg LE, et al. Proc Natl Acad Sci USA. 1991; 88:603-7
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