Clone Number: 10F11
Immunogen: Prokaryotic recombinant protein corresponding to a region of the N-terminal intracellular domain of the human CD71 molecule.
Concentration: Greater than or equal to 42 mg/L
Storage buffer: Tissue culture supernatant with sodium azide
Additional info: The CD71 molecule is a type II membrane glycoprotein with a molecular weight of approximately 180 kD. It is known as the transferrin receptor and is composed of two disulfide-bonded 90 kD subunits. The CD71 molecule plays a critical role in cell proliferation by controlling the supply of iron, an essential component for many metabolic pathways, through the binding and endocytosis of transferrin, the major iron-carrying protein. CD71 protein is reported to be expressed on activated B and T cells, macrophages, proliferating cells and metabolically active cells, for example, neurons.
References: Dong HY et al. American Journal of Surgical Pathology. 2011; 35(5):723-732/Magro G et al. Thyroid. 2011; 21(3):267-277/Menier C et al.Blood. 2004; 104(10):3153-3160
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