Clone Number: EBS-CD-009
Immunogen: human PBL
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: EBS-CD-009 recognizes a protein of 32 kDa, identified as CD8a. The CD8 molecule consists of α and βchain, which are disulphide-linked into heterodimers or homodimers. CD8 is expressed on a T-cellsubset (cytotoxic/suppressor T-cells), thymocytes and NK-cells. The majority of CD8+ T-cells expressCD8 as heterodimer. Some subpopulation of SD8+ T-cells as well as NK-cells may expresshomodimer. CD8 functions as a co-receptor in concert with TCR for binding the MHC class I/peptidecomplex. HIV-2 envelope glycoprotein binds CD8 α-chain but not β-chain.
References: Knapp W. et. al. Leukocyte Typing IV, p342-343, (1989)/Parnes JR, Semin Immunol 6: 221-229 (1994)/Delon J. et al. Immunity 9(4): 467-73 (1998)
English
Deutsch
