Clone Number: EBS-CD-007
Immunogen: human PBL
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: EBS-CD-007 recognized a protein of 32 kDa, identified as CD8b. The CD8 molecule consists of α and β chains, which are disulphide-linked into heterodimers or homodimers. CD8 is expressed on a T-cell subset (cytotoxic-suppressor T-cells), thymocytes and NK cells. The majority of CD8+ T-cells express CD8 as heterodimer. Some subpopulation of CD8+ T-cells as well as NKcells may express homodimer. CD8 functions as a co-receptor is concert with TCR for binding the MHC class I/peptide complex. HIV-2 envelope glycoprotein binds CD8 α chain but not β chain.
References: Knapp W. et. al. Leukocyte Typing IV, p342-343, Oxford University Press, 1989/Parnes JR, Semin Immunol 6: 221-229 (1994)/Hadi Hossein Nataj Arab et al., Gastroenterol Hepatol Bed Bench. 8(2): 132–139 (2015)
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