Clone Number: B-R18
Immunogen: recombinant Fas antigen
Concentration: 100 ug/ml
Storage buffer: PBS with 0.02% sodium azide
Additional info: B-R18 specifically recognizes CD95. CD95 is a cell surface glycoprotein with a MW of 40-45 kDa and contains 8 kDa of N-glyosidic-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. CD95 is preferentially expressed by the CD54RAlow and CD45ROhigh subset of memory T-cells, but it also found on peripheral monocytes. It is further found on human B-cell lines like pre-B cells, EBV infected cells, Burkitt cells and plasmacytoma cells. It also binds to human T-cell lines, myeloid cell lines, hepatocyte carcinoma and endothelial cells.
References: Sasaki et al. Br J Urol 81: 852, (1998)/Sugihara et al. Anticancer Res 17: 3861, (1997)/Kondo et al. J Pathol 183: 75, (1997)
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