Mouse anti-CIP2A Monoclonal Antibody, Affinity Purified (2A1-9A4)

Stock Concentration: 1000 µg/ml

Conjugate Type: Unconjugated

Buffer: Tris-buffered Saline containing 0.09% Sodium Azide, BSA-Free

Shelf Life: 1 year from date of receipt

Protein ID: NP_065941.1

Uniprot ID: Q8TCG1

Background: CIP2A (cancerous inhibitor of PP2A) was originally identified as p90, a cytoplasmic autoantigen found in the serum from a cancer patient. It was later described as a protein that interacted with the c-myc oncogene and functioned as an inhibitor of protein phosphatase 2A (PP2A) activity. Inhibition of PP2A phosphatase activity by CIP2A prevents c-myc phosphorylation and counteracts c-myc proteolytic degradation, thereby stabilizing c-myc and promoting cell growth and transformation. CIP2A is found to be overexpressed in some human malignancies and is thus classified as an oncogene that may be an important contributor to tumor formation.

Immunogen: Amino terminal one-third of the CIP2A (GeneID 57650) recombinant protein

• SKU: BEYA500-010ACF
• Manufacturer: Bethyl Laboratories
• Manufacturer SKU: A500-010ACF
• Green Labware: No
• Package Unit: 100 µl
• Quantity Unit: STK
• Reactivity: Human, Mouse (Murine)
• Clonality: Monoclonal
• Application: Immunoprecipitation, Western Blotting
• Isotype: Whole IgG
• Human Gene ID: 57650
• Host: Mouse