Clone Number: DBN-N-03
Immunogen: Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326)
Concentration: 1 mg/ml
Format: Purified by protein-A affinity chromatography.
Storage buffer: Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
Additional info: Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse.SpecificityThe mouse monoclonal antibody EGFR1 reacts with extracellular domain of human protein kinase EGFR (ErbB1 / HER1); epitope within amino acids 6-273.Application detailsWestern blotting: Positive control: REH, Nalm-6, HEK293 cells.
Flow cytometry: Recommended dilution: 1-4 µg/ml. Intracellular staining.
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