Mouse anti-Granzyme B, clone 11F1 (monoclonal)

Clone Number: 11F1

Immunogen: Recombinant prokaryotic fusion protein corresponding to the N-terminus of the mature granzyme B molecule.

Concentration: Greater than or equal to 47 mg/L

Storage buffer: Tissue culture supernatant with Sodium azide

Additional info: Granzymes are neutral serine proteases which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTL) and in natural killer (NK) cells. These CTL and NK cells are heavily involved in the elimination of neoplastic and virally infected cells. Secretory granules containing perforin and granzymes are instrumental in undertaking cytolytic activity. Granzyme B is understood to enter a target cell through a perforin pore-formed channel to induce DNA fragmentation and apoptosis. Granzyme B has also been described in neoplastic CTL and NK cells.

References: Lee HK et al. J Korean Med Sci. 2003; 18:272–276/Theate I et al.European Journal of Haematology. 2002; 69(4):248–253

• SKU: SANMONX10609
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MONX10609
• Green Labware: No
• Package Unit: 1 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunohistochemistry (paraffin)
• Isotype: IgG2a
• Host: Mouse