Mouse anti-Granzyme B, clone GrB-7 (Monoclonal)

Clone Number: GrB-7

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: 100 ug/ ml

Format: Protein G purified

Storage buffer: PBS with 0.1% BSA and 0.1% sodium azide

Additional info: The antibody reacts with the 33 kD human serine protease granzyme B. It does not react with human granzyme A. It is used as a marker for NK-cells and activated cytotoxic T-cells (CTL). This protease is localized in cytoplasmic granules and gives a granular staining pattern. Granzyme B is involved in target cell apoptosis during lymphocyte mediated cyto-toxicity. Exocytosis of granzyme containing granules in the cytoplasm of the target cell will lead to induction of DNA fragmentation and apoptosis of the target cell.

References: Kummer, J.A et al. J. Immunol. Methods 1993; 163: 77/Kummer, J.A et al.Clin. Exp. Immunol. 1995;100: 164/de Bruin, P.C. et al. Blood 1994; 84: 3785-3791

• SKU: SANMON7029C
• Manufacturer: Sanbio / Monosan
• Manufacturer SKU: MON7029C
• Package Unit: 1 ml
• Quantity Unit: STK
• Reactivity: Human
• Clonality: Monoclonal
• Application: Immunohistochemistry (paraffin), ELISA, Immunocytochemistry
• Isotype: IgG2a
• Host: Mouse
• Conjugate: Unconjugated