Clone Number: MBH90B
Immunogen: Peptide corresponding to the EEVHHGEEEVEC sequence within N-terminal part of human Hsp90.
Concentration: 1 mg/ml
Format: Purified by protein-A affinity chromatography.
Storage buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Additional info: Hsp90 beta (heat shock protein 90 beta) is a constitutively expressed isoform of Hsp90, one of the most abundant chaperones in the cytosol of eukaryotic cells. Hsp90 interacts with various proteins, including protein kinases and transcription factors, and either facilitates their stabilization and activation or directs them for proteasomal degradation. Hsp90 thus affects multiple signaling pathways and biological processes and modulation of this single target offers the prospect of simultaneous intervence to various key points of oncogenic transformation. Hsp90 operates as a dimer in a conformational cycle driven by ATP binding and hydrolysis.SpecificityThe mouse monoclonal antibody Bcl-2/100 recognizes Bcl2, a 26 kDa intracellular protooncogen with anti-apoptotic effect, expressed in outer mitochondrial membrane, endoplasmic reticulum and nuclear envelope.Application detailsWestern blotting: Recommended dilution: 1 μg/ml.
Immunocytochemistry: Recommended dilution: 1 μg/ml.
Immunoprecipitation: Recommended dilution: 1 μg/ml.
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