Clone Number: T21/8
Immunogen: CCR5 peptide (Met1-Lys22) KLH conjugate
Concentration: 1 mg/ml
Format: Purified by protein-A affinity chromatography.
Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Additional info: CD195 / CCR5 (also known as CKR-5) is a receptor for inflammatory CC-chemokines (characterized by a pair of adjacent cysteine residues), such as MIP-1 alpha, MIP-1 beta, or RANTES. It is a G protein-associated seven-pass transmembrane protein expressed on resting T cells with memory/effector phenotype, monocytes, macrophages and immature dendritic cells. This chemokine receptor regulates the activation and directed migration of leukocytes. Importantly, along with CD4, CD195 / CCR5 functions as a major receptor for HIV. Their ligand is the viral glycoprotein gp120.SpecificityThe mouse monoclonal antibody C9Mab-1 recognizes an extracellular epitope of CD199, a 7-transmembrane chemokine receptor.Application detailsWestern blotting: Do not boil cell lysates prior to SDS-PAGE.
Flow cytometry: Recommended dilution: 1-4 µg/ml
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