Clone: 2D2.
Background: The immunogen for the anti-h bax was a synthetic peptide corresponding to amino acids 3 to 16 of the human bax sequence. Bax expression is associated with cell death regulation. The ratio of bax to other bcl-2 family members is believed to regulate apoptosis.
Immunogen: A synthetic peptide corresponding to amino acids 3 to 16 of the human bax sequence.
Purification Method: Protein A/G Chromatography.
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide.
References: 1. Y.T. Hsu et. al. (1997) J. Biol. Chem., 272(21): 13829-13834
2. Y. T. Hsu et. al (1997) Proc. Natl. Acad. Sci. USA, 94: 3668-3672
3. Annis, M., et al, 'Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis' EMBO Journal 2005, 24, , 2096-2103
4. Soucie, E.L., et al, 'Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria' Molecular and Cell Biology 2001, 21, , 4725-4736.
UniProt: Q07812 - Bax-alpha
Q07814 - Bax-beta.
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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