Clone: J5511
Background: Identification of human NK cell antigen expressing the 50 -70 kDa M.W. surface antigen associated with the IgG Fc receptor III on NK cells and Neutrophils. CD16 is expressed on approximately 15% of peripheral blood lymphocytes and is present on all resting NK cells. CD16 may be expressed on CD3 T cells from certain individuals.
Immunogen: CD16=Derived from the hybridization of mouse P3-X63-Ag8.653 myeloma cells with spleen cells of BALB/c mice immunized with NK lymphocytes
Purification Method: Protein A/G Chromatography
Concentration: Titered for flow cytometry
Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide and 0.2% carrier protein
References: 1. CD16 on human gamma delta T lymphocytes: expression, function, and specificity for mouse IgG isotypes. Braakman E; van de Winkel JG; van Krimpen BA; Jansze M; Bolhuis RL Cell Immunol 1992 Aug;143(1):97-107 2. Fc gamma RIII activation is different in CD16+ cytotoxic T lymphocytes and natural killer cells. Uciechowski P; Gessner JE; Schindler R; Schmidt RE Eur J Immunol 1992 Jun;22(6):1635-8 3. Involvement of a metalloprotease in spontaneous and phorbol ester-induced release of natural killer cell-associated Fc gamma RIII (CD16-II). Harrison D; Phillips JH; Lanier LL J Immunol 1991 Nov 15;147(10):3459-65 4. CD16- CD56+ natural killer cells after bone marrow transplantation. Jacobs R; Stoll M; Stratmann G; Leo R; Link H; Schmidt RE Blood 1992 Jun 15;79(12):3239-44 5. Natural killer function in flow cytometry: identification of human lymphoid subsets able to bind to the NK sensitive target K562. Vitale M; Zamai L; Neri LM; Manzoli L; Facchini A; Papa S Cytometry 1991;12(8):717-22 6. In vitro responsiveness to interleukins and theophylline of CD16+, CD56- natural killer cells in a patient with chronic granular lymphocyte disorder. Bayle C; Vitte-Mony I; Lang P; Pico J; Hercend T; Bertoglio J Leukemia 1992 May;6(5):470-6 7. Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain. Wirthmueller U; Kurosaki T; Murakami MS; Ravetch JV J Exp Med 1992 May 1;175(5):1381-90
UniProt: Q9ULV2
Caution: This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals.
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