Clone Number: UIC2
Immunogen: Mouse Balb/c 3T3 fibroblasts transfected with human CD243 cDNA
Concentration: IgG 1 mg/ml
Format: Purified
Storage buffer: PBS with <0.1% sodium azide
Additional info: Mouse anti Human CD243, clone UIC2 recognizes an extracellular conformational epitope of CD243, also known as MDR1 (multi-drug resistance protein 1) and Pgp (P-glycoprotein), a multi pass transmembrane protein and member of the ABC transporter (ATP-binding cassette) family, containing two ABC transporter type 1 domains and two ABC transporter domains. CD243 acts as an active efflux pump for a diverse range of lipophillic compounds. CD243 is expressed at low levels in the cell membrane of peripheral blood leucocytes, and constitutively expressed on the apical plasma membrane of excretory epithelial cells of the kidney, liver, brain and small intestine. CD243 mediates resistance to manychemotherapeutic agents used for tumour suppression and is therefore of special interestto oncologists. Clone UIC2 is a strong inhibitor of CD243-mediated efflux and of theresistance of MDR cells to CD243 transported cytotoxic drugs.
References: Mechetner EB et al. PNAS 1992; 89: 5824-8/Park SW et al. Cytometry part A 2003; 53A: 67-78/Koziolek MJ et al. Kidney Int 2001; 60: 156-66
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