Clone Number: 4B7R
Immunogen: Occular melanoma cell line V+B2
Concentration: IgG 1 mg/ml
Format: Purified
Storage buffer: PBS with <0.1% sodium azide
Additional info: Mouse anti Human CD29 monoclonal antibody, clone 4B7R recognizes the human integrin beta 1 subunit, also known as CD29, a ~130 kDa (red) 115 kDa (non-red) single pass type I transmembrane glycoprotein expressed by most leucocytes and mesenchymal stem cells.Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis and prevention ofprogrammed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. Surface expression of CD29 on human natural killer cells can be reduced by pretreatment with the glutathioneS-transferase inhibitor diethyl maleate (Horvath-Arcidiacono et al. 2003)
References: Marshall HF et al. Br J Cancer 1998; 77: 522-9/Pillay J et al. J Leukoc Biol 2010; 88: 211-20/Horvath-Arcidiacono JA et al. Cell Immunol 2011; 222: 35-44
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